1,5-benzodiazepine compounds, their production and use

A method for regulating a somatostatin receptor function which comprises administering a compound represented by the formula (I)

• 29
• [wherein ring B represents a cyclic hydrocarbon group which may have substituent(s);
• Z represents hydrogen atom or a cyclic group which may have substituent(s);
• R1 represents hydrogen atom, a hydrocarbon group which may have substituent(s), a heterocyclic group which may have substituent(s) or an acyl group;
• R2 represents amino group which may have substituent(s);
• D represents a bond or a divalent group;
• E represents a bond, —CO—, —CON(Ra)—, —COO—, —N(Ra)CON(Rb)—, —N(Ra)COO—, —N(Ra)SO2—, —N(Ra)—, —O—, —S—, —SO— or —SO2— (Ra and Rb each independently represents hydrogen atom or a hydrocarbon group which may have substituent(s));
• G represents a bond or a divalent group;
• L represents a bond or a divalent group;
• A represents hydrogen atom or a substituent;
• X and Y each represents hydrogen atom or an independent substituent;
• and . . . represents that R2 and an atom on ring B may form a ring] or a salt thereof.

Use of a compound represented by the formula (I)

• 30
• [wherein ring B represents a cyclic hydrocarbon group which may have substituent(s);
• Z represents hydrogen atom or a cyclic group which may have substituent(s);
• R1 represents hydrogen atom, a hydrocarbon group which may have substituent(s), a heterocyclic group which may have substituent(s) or an acyl group;
• R2 represents amino group which may have substituent(s);
• D represents a bond or a divalent group;
• E represents a bond, —CO—, —CON(Ra)—, —COO—, —N(Ra)CON(Rb)—, —N(Ra)COO—, —N(Ra)SO2—, —N(Ra)—, —O—, —S—, —SO— or —SO2— (Ra and Rb each independently represents hydrogen atom or a hydrocarbon group which may have substituent(s));
• G represents a bond or a divalent group;
• L represents a bond or a divalent group;
• A represents hydrogen atom or a substituent;
• X and Y each represents hydrogen atom or an independent substituent;
• and . . . represents that R2 and an atom on ring B may form a ring] or a salt thereof, for manufacturing a medicament for regulating a somatostatin receptor function.