Therapeutic compounds

A compound of Formula I:

• 45
• wherein
• X is O, S, or N—Rb;
• R1 is —Y—Q—Z;
• Y is heterocycle, substituted heterocycle, heteroaryl, or substituted heteroaryl,
• Q is absent, —O—, —S(O)m—, —NRa—, or alkylene;
• Z is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl, or absent provided that Q is also absent;
• R2 is H, C1-8alkyl, or aryl(C1-8alkylene-);
• R3, R4, R5, and R6 are each independently H, hydroxy, nitro, halo, cyano, N3, amidine, guanidine, thioguanidine, cyanoguanidine, C1-8alkyl, C1-8haloalkyl, C1-8alkoxy, C1-8haloalkoxy, C3-8cycloalkyl, aryl, heteroaryl, substituted heteroaryl, —S(O)NRcRd, —S(O)2NRcRd, —NRcRd, —S(O)mRa, —C(═O)NRcRd, —C(═S)NRcRd, —N(Ra)—S(O)Ra, or —N(Ra)—S(O)2Ra;
• each Ra is independently H, C1-8alkyl, C1-8alkanoyl, C1-8alkoxycarbonyl, aryl, aryl(C1-8alkylene-), heteroaryl, heteroaryl(C1-8alkylene-), heterocycle, or heterocycle(C1-8alkylene-);
• Rb is hydrogen, C1-8alkyl, C1-8alkanoyl, C1-8alkoxycarbonyl, cyano, aryl, aryl(C1-8alkylene-), heteroaryl, heteroaryl(C1-8alkylene-), heterocycle, or heterocycle(C1-8alkylene-);
• each of Rc and Rd is independently H, C1-8alkyl, C1-8alkanoyl, C1-8alkoxycarbonyl, aryl, aryl(C1-8alkylene-), heteroaryl, heteroaryl(C1-8alkylene-), heterocycle, or heterocycle(C1-8alkylene-);
• or Rc and Rd together with the nitrogen to which they are attached form azepino, piperazino, pyrrolidino, piperidino, morpholino, or thiomorpholino ring;
• each m is independently 0, 1, or 2;
• or a pharmaceutically acceptable salt thereof.