Novel carbapenem derivatives

A compound represented by the formula (I), or a pharmaceutically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:

• 238
• wherein
• R1 represents a hydrogen atom or a methyl group,
• R2, R3, R4, and R5, either one of which represents the bonding to the 2-position on the carbapenem ring, and the other three of which may be the same or different, respectively represent
• a hydrogen atom,
• a halogen atom,
• a nitro group,
• a cyano group,
• a lower alkyl group which may be substituted,
• a lower cycloalkyl group which may be substituted,
• a lower alkylthio group,
• an arylthio group,
• a C2-4 alkenyl group which may be substituted,
• a formyl group.
• a lower alkylcarbonyl group which may be substituted,
• a lower alkoxycarbonyl group,
• a lower alkylsulfonyl group,
• an arylsulfonyl group which may be substituted,
• an aminosulfonyl group,
• an N-loweralkylaminosulfonyl group,
• an N,N-di-lower alkylaminosulfonyl group,
• an N-lower alkoxy-N-lower alkylaminosulfonyl group,
• a lower alkylsufinyl group,
• an arylsulfinyl group,
• an aminosulfinyl group,
• an arylcarbonyl group,
• an aryl group which may be substituted,
• a carbamoyl group,
• an N-lower alkylcarbamoyl group,
• an N,N-di-lower alkylaminocarbonyl group,
• a lower alkoxyiminomethyl group,
• a hydroxyiminomethyl group, or
• a five- or six-membered aromatic heterocyclic ring having one or more hetero atoms selected from nitrogen, oxygen and sulfur atoms, and
• R represents a hydrogen atom or a group which may be hydrolyzed in organisms.