Methods of treating bacterial infections in dogs and cats

A pharmaceutical composition for treating opportunistic bacterial infections resulting from (a) a compromised or diminished immunological system, (b) Feline Immunodeficiency Virus (FIV) or (c) cancer chemotherapy in or on a dog or cat comprising a therapeutically effective amount of a compound of Formula I,

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• wherein R1 is h, a pharmaceutically acceptable cation salt, or an in vivo hydrolysable group capable of generating CO2H, and R2 is C1-4 alkyl, and a pharmaceutical diluent or carrier.

A pharmaceutical composition for treating a disease or condition caused by a bacterial infection in a dog or cat comprising a therapeutically effective amount of a compound of Formula I,

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• wherein R1 is H, a pharmaceutically acceptable cation salt, or an in vivo hydrolysable group capable of generating CO2H, and R2 is C1-4 alkyl, and a pharmaceutical diluent or carrier, with the proviso that if the pharmaceutically acceptable cation salt is Na, Li or K, R2 is not methyl.

A method of treating periodontal disease or an opportunistic bacterial infection in or on a dog or cat, resulting from (a) a compromised or diminished immunological system, (b) Feline Immunodeficiency Virus (FIV) or (c) cancer chemotherapy in or on a comprising administrating a therapeutically effective amount of a compound of Formula I

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• wherein R1 is H, a pharmaceutically acceptable cation salt, or an in vivo hydrolysable group capable of generating CO2H, and R2 is C1-4 alkyl, effective in treating such a condition.

A method of treating a disease or condition caused by a bacterial infection in or on a dog or cat comprising administrating a therapeutically effective amount of a compound of Formula I,

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• wherein R1 is H, a pharmaceutically acceptable cation salt, or an in vivo hydrolysable group capable of generating CO2H, and R2 is C1-4 alkyl, and a pharmaceutical diluent or carrier, with the proviso that if the pharmaceutically acceptable cation salt is Na, Li or K, R2 is not methyl, effective in treating such a condition.

A method for increasing acute or chronic injection-site toleration in a dog or a cat, comprising administering to a dog or a cat in need thereof a single dose of a therapeutically effective amount of a Formula I

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• wherein R1 is H, a pharmaceutically acceptable cation salt, or an in vivo hydrolysable group capable of generating CO2H, and R2 is C1-4alkyl, effective in treating such a condition.