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US 2003/0149008 A1Published application
Hormonal implants treatment of the breast cancer
OwnerVelayudhan Sahadevaninventor
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OwnerVelayudhan Sahadevaninventor
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An improved method and products for the hormonal treatment of breast cancer by breast implants of anti-estrogens and steroid hormones in formulations as fused with a lipoid carrier or encapsulated in microcapsules or in Silastic capsules is provided. Such breast implants renders a constant slow-release of their contents to the breast tissue for extended periods by biodegradation and diffusion. It facilitates higher breast tissue concentrations of anti-estrogen and hormonal compositions. Because of their high concentration in the breast and lower systemic distribution, tumor control is much improved and the their systemic toxicity is minimized. An added beneficial effect of these breast implants on breast cancer is mediated by the inhibition of hypothalamic-pituitary LHRH, FSH and LH secretion by these composition's systemic contents. It is also an effective prophylaxis against breast cancer. Furthermore, it reduces the cost of hormonal treatment of breast cancer. Anti-estrogen hormonal implants to the breast as concomitant hormonal treatment with conventional radiation therapy also facilitates improved tumor control and cure rates of breast cancer.
An improved method of hormonal treatment of breast cancer and said hormonal treatment comprising of breast implants of anti-estrogens and steroid hormones, or its synthetic derivatives in one or more slow release formulations and permitting said drugs to be continuously released at near constant rate directly to the breast for longer periods with minimal or no systemic toxicity.
An improved method of concomitant hormonal and radiation treatment of the breast cancer and said hormonal treatment comprising of breast implants of anti-estrogens and steroid hormones in one or more slow release formulations and permitting said drugs to be continuously released at near constant rate directly to the breast during the radiation therapy and afterwards for longer periods.
An improved method of treating hormone dependent and hormone refractory breast cancer and its accessible metastasis by implanting combinations of hormones and anti-estrogens to said tumor sites for improved tumor control with lesser toxicity than by administering said hormonal compositions at higher doses by mouth, subcutaneous, intramuscular or intravenous routes and said hormone compositions containing in one or more slow release implant formulations.
Slow-release anti-cancer breast implants products for treatment of breast cancer and comprising of anti-estrogens and steroid hormones as fused with a lipoid carrier or as encapsulated in Silastic capsules or as injectable microcapsules and are suitable for breast implantation such that said hormonally and cytotoxically effective compositions are continuously released at relatively high constant rates to the breast.
A slow-release hormonal breast implant method and products comprising single or synergetic combination of hormonally and cytotoxically effective compositions selected from the an anti-estrogen groups of tamoxifen, raloxifene, or toremifene and a progesterone composition selected from the group consisting of megestrol acetate, medroxyprogesterone, norethindrone acetate norgestrel and from the corticosteroids group prednisolone and they are fused with a lipoid carrier or encapsulated in Silastic capsules or formulated as injectable microcapsules as suitable slow-release breast implantation and implanting said products for the treatment of early and advanced stage breast cancers and as hormonal treatment combined with radiation.
Dependencies are inferred from the claim text.