Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
AssigneeSky High, LLC
InventorsJ. Graham Goddard, Samiul R. Umansky, John D. Bradley, Ian C. Bathurst, Matthew W. Foehr, Donald H. Picker
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Abstract
The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.
Claims109
A composition comprising a therapeutically effective amount of an LPA and a potentiating component in an amount sufficient to potentiate the therapeutic effectiveness of the LPA.
A method of treating apoptosis or preserving or restoring function, in a cell, tissue or organ, comprising administering a therapeutically effective amount of a pharmaceutically acceptable composition comprising lysophosphatidic acid or an analog thereof (LPA).
A method of treating apoptosis, preserving or restoring function in a cell, tissue or organ comprising administering internally or in vitro a therapeutically effective amount of a pharmaceutically acceptable composition comprising lysophosphatidic acid or an analog thereof (LPA) to cells.
A composition, comprising:
- a compound of the following formula
- 44
- or a cyclic phosphate derivative thereof having the structure:
- 45
- wherein
- each X is independently O or S;
- each W is independently SH, OH, OCH2CH(NH2)CO2H, OCHCH3CH(NH2)CO2H, OPO3H2, or OPO2HOPO3H2, where if one W is OPO3H2 or OPO2HOPO3H2, the remaining W is OH;
- Z is OH, SH, NH2, halogen, OPO3H2, H, O(CH2)bCH3 where b=0 to about 2, or SO3H;
- R is unsubstituted or substituted, saturated or unsaturated, straight or branched-chain alkyl having from about 10 to about 24 carbon atoms, or ((CH2)mO)p(CH2)mW where p is an integer from 1 to about 900 and where each m is independently an integer from 2 to about 10 and W is OH, or O(CH2)qCH3 where q is an integer from 0 to about 10;
- Y is O or S;
- and
- n is an integer from 0 to about 10;
- or a salt thereof.
A composition, comprising:
- 3-O-Oleoyl-2-O-methyl-rac-glycero-1-thiophosphate, or a salt thereof.
A composition comprising:
- Oleyl 1-thiophosphoryl-2-O-methyl-rac-glycerate, or a salt thereof.
A composition, comprising:
- 3-O-Oleyl-2-O-methyl-rac-glycero-1-thiophosphate, or a salt thereof.
Dependencies are inferred from the claim text.