Use of cyclodextrins to modulate gene expression with reduced immunostimulatory response
OwnerQiuyan Zhao, Jamal Temsamani +1inventors
InventorsQiuyan Zhao, Jamal Temsamani, Sudhir Agrawal
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Abstract
The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by administering the phosphorothioate oligonucleotide in a therapeutic formulation which includes at least one cyclodextrin to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
Claims9
A method of reducing an immunostimulatory response of a mammal to a phosphorothioate oligonucleotide which comprises the steps of:
- a) administering a therapeutic formulation containing the phosphorothioate oligonucleotide and at least one cyclodextrin to the mammal;
- and
- b) monitoring the immune response of the mammal.
A method of reducing an immunostimulatory response of a mammal to a protein which comprises the steps of:
- a) administering a therapeutic formulation containing the protein and at least one cyclodextrin to the mammal;
- and
- b) monitoring the immune response of the mammal.
Dependencies are inferred from the claim text.