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US 2003/0148980 A1Published application
Hybrid oligonucleotide phosphorothioates
AssigneeWorcester Foundation for Experimental Biology
InventorsValeri Metelev, Sudhir Agrawal
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Abstract
The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
Claims16
A hybrid oligonucleotide phosphorothioate or phosphorodithioate comprising one each of the following:
- a deoxyribonucleoside, a ribonucleoside or a 2′-substituted ribonucleoside, and a phosphorothioate or phosphorodithioate internucleotide linkage.
Dependencies are inferred from the claim text.