Method of achieving persistent transgene expression
OwnerDavid Ennist, Patrick Lu +1inventors
InventorsDavid Ennist, Patrick Lu, Mervat Mina
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Abstract
Non-inflammatory vector compositions are provided that are suitable for repeated transgene delivery and that result in persistent transgene expression. The compositions are non-inflammatory, the present compositions are suitable for readministration and do not induce expression-limiting immune or inflammatory responses. Thus, these compositions are useful in methods of repeated administration to achieve persistent transgene expression, and are especially suited to treating genetic, acquired and inflammation-associated conditions.
Claims20
A non-inflammatory vector composition, comprising (i) aqueous free nucleic acid that encodes a gene product and (ii) an antiinflammatory compound.
A method of treating a patient suffering from a disorder having an inflammatory component, comprising at least twice administering to the patient an effective amount of a non-inflammatory vector composition, comprising (i) aqueous free nucleic acid that encodes a gene product and (id) an enhancing agent.
A method of treating a patient suffering from a disorder having an inflammatory component, comprising at least twice administering to the patient an effective amount of a non-inflammatory vector composition, comprising (i) aqueous free nucleic acid that encodes a gene product and (ii) an immunosuppressive agent.
Dependencies are inferred from the claim text.