Back to results
US 2003/0148971 A1Published application
Treatment of inflammatory and malignant diseases
OwnerMalcolm Lovell Handel, Ly Quoc Quynh Nguyen +2inventors
InventorsMalcolm Lovell Handel, Ly Quoc Quynh Nguyen, David G. Atkins, Murray John Cairns
Life of this patent
Estimating the term…
Abstract
The present invention relates to DNAzymes which are targeted against mRNA molecules encoding RelA(p65) (a subunit of NF-κB). The present invention also relates to compositions including these DNAzymes and to methods of treatment involving administration of the DNAzymes.
Claims18
A DNAzyme which specifically cleaves RelA(p65) mRNA, the DNAzyme comprising
- (i) a catalytic domain which cleaves mRNA at a purine:pyrimidine cleavage site;
- (ii) a first binding domain contiguous with the 5′ end of the catalytic domain;
- and
- (iii)a second binding domain contiguous with the 3′ end of the catalytic domain,
- wherein the binding domains are sufficiently complementary to the two regions immediately flanking a purine:pyrimidine cleavage site within the region of RelA(p65) mRNA corresponding to nucleotides 1 to 1767 as shown in SEQ ID NO:
- 1, such that the DNAzyme cleaves the RelA(p65) mRNA.
3 more elements
Dependencies are inferred from the claim text.