Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
OwnerH. Kirk Hammond, Wolfgang Dillmann +1inventors
InventorsH. Kirk Hammond, Wolfgang Dillmann, Frank J. Giordano
Life of this patent
Estimating the term…
Abstract
Methods are provided for treating patients with cardiovascular disease, including heart disease and peripheral vascular disease. The preferred methods of the present invention involve in vivo delivery of genes, encoding angiogenic proteins or peptides, to the myocardium or to peripheral ischemic tissue, by introduction of a vector containing the gene into a blood vessel supplying the heart or into a peripheral ischemic tissue.
Claims156
A method for increasing contractile function in the heart of a patient, comprising delivering a transgene encoding an angiogenic protein or peptide to the myocardium of the patient by introducing a vector comprising the transgene into at least one coronary artery, wherein the transgene is delivered to the myocardium and expressed, and contractile function in the heart is increased.
A method for increasing blood flow in an ischemic tissue of a patient, comprising delivering a transgene encoding an angiogenic protein or peptide to an ischemic region of said tissue by introducing a vector comprising the transgene to said tissue, whereby the transgene is expressed in the tissue, and blood flow in the tissue is increased.
The method of claim 62, wherein the blood vessel is selected from the group consisting of a coronary artery and a femoral artery.
A gene therapy composition comprising a vector containing a transgene encoding an angiogenic protein or peptide.
Dependencies are inferred from the claim text.