Combination therapy of angiotensin converting enzyme inhibitor and side-effect-reduced amount of aldosterone antagonist for treatment of cardiovascular disease
AssigneeG.D. Searle & Co.
InventorsTodd E. MacLaughlan, Alfonso T. Perez
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Abstract
Combinations of an ACE inhibitor and an aldosterone receptor antagonist are described for use in treatment of circulatory disorders. Of particular interest are therapies using captopril or enalapril co-administered with a low-dose of spironolactone. This co-therapy would be particularly useful to treat or prevent the progression of congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia.
Claims30
A combination comprising a therapeutically-effective amount of an angiotensin converting enzyme inhibitor and an aldosterone receptor antagonist, said aldosterone receptor antagonist being present in an amount which is therapeutically effective to antagonize a physiological effect of aldosterone but which amount is not sufficient for said aldosterone receptor antagonist to cause a substantial diurectic effect.
A co-therapy for treating a cardiovascular disorder in a subject afflicted with or susceptible to multiple cardiovascular disorders, wherein said co-therapy comprises administering a therapeutically-effective amount of an angiotensin converting enzyme inhibitor and administering an aldosterone receptor antagonist in an amount therapeutically effective to antagonize aldosterone but insufficient to cause substantial diuretic effect.
A pharmaceutically-acceptable dosage form comprising one or more excipients and a fixed combination consisting of two cardiovascular drug components, wherein said first drug component is an ACE inhibitor and said second component is spironolactone, wherein said first and second components are present in the dosage form in a weight ratio of said-first-component-to-said-component in a range from about 0.1-to-one to about 25-to-one.
Dependencies are inferred from the claim text.