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US 2003/0148956 A1Published application
Corticotropin releasing factor 2 receptor agonists
AssigneeThe Procter & Gamble Company
InventorsRobert Joseph Isfort, Wieslaw Adam Mazur
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Abstract
Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy.
Claims14
A non-native peptide comprising the sequence
- —X2X3PSLSIDX10PX12X13X14LLRTLLELEKTQSQRERAEQNAX36IFAX40V
- wherein;
- X2 is selected from nil and D;
- X3 is selected from nil and N;
- X10 is selected from L and V;
- X12 is selected from L, and F;
- X13 is selected from L, F, and Y;
- X14 through X35 comprises the sequence
- X36 is selected from R, H, and Q;
- X40 is selected from H and R;
- and variants thereof:
8 more elements
The method according to claim 20, wherein the CRF2R modulated disorder is skeletal muscle atrophy or a form of muscular dystrophy.
Dependencies are inferred from the claim text.