Super-active porcine growth hormone releasing hormone analog
AssigneeBaylor College of Medicine
InventorsRobert J. Schwartz, Ruxandra Draghia-Alki
Life of this patent
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Abstract
Inadequate growth due to deficiencies in growth hormone (GR), growth hormone releasing hormone (GHRH), or genetic diseases can be ameliorated utilizing recombinant protein therapy with a novel GHRH analog having a sequence (SEQ ID NO:1). Also included is (1) a method of treating growth hormone-related deficiencies associated with the growth hormone pathway; (2) a method for treating growth hormone-related deficiencies associated with genetic disease; (3) a method to improve growth performance in an animal; (4) a method of treating an animal having a growth deficiency disease; (5) a method of increasing the efficiency of an animal used for food; and. (6) a method to enhance growth in an animal.
Claims21
As a composition of matter, growth hormone-releasing hormone having an amino acid sequence of SEQ ID NO:
- 1.
As a composition of matter, a nucleotide sequence encoding the growth hormone-releasing hormone having the amino acid sequence of SEQ ID NO:1.
A vector comprising a promoter;
- a nucleotide sequence encoding SEQ ID NO:1;
- and a 3′ untranslated region operatively linked for functional expression.
A method of treating growth hormone-related deficiencies associated with the growth hormone pathway in an animal comprising the step of introducing a therapeutically effective amount of a vector into an animal, said vector comprised of a synthetic myogenic promoter;
- a nucleotide sequence encoding SEQ ID NO:1;
- and the 3′ untranslated region of hGH operatively linked for functional expression.
A method for stimulating production of growth hormone in an animal at a level greater than that associated with normal growth, said method comprising introducing into said animal a therapeutically effective amount of a vector, said vector comprising a synthetic myogenic promoter;
- a nucleotide sequence encoding SEQ ID NO:1;
- and a 3′ untranslated region of hGH operatively linked for functional expression.
Dependencies are inferred from the claim text.