Major intrinsic protein (MIP)-like polynucleotides, polypeptides and antibodies
AssigneeHuman Genome Sciences, Inc.
InventorsSteven M. Ruben, Jian Ni
Life of this patent
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Abstract
The present invention relates to novel human MIP-like polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human MIP-like polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human MIP-like polypeptides.
Claims22
An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- (a) the polynucleotide shown as SEQ ID NO:X or the polynucleotide encoded by a cDNA included in ATCC Deposit No:Z;
- (b) a polynucleotide encoding a biologically active polypeptide fragment of SEQ ID NO:Y or a biologically active polypeptide fragment encoded by the cDNA sequence included in ATCC Deposit No:Z;
- (c) a polynucleotide encoding a polypeptide epitope of SEQ ID NO:Y or a polypeptide epitope encoded by the cDNA sequence included in ATCC Deposit No:Z;
- (d) a polynucleotide capable of hybridizing under stringent conditions to any one of the polynucleotides specified in (a)-(c), wherein said polynucleotide does not hybridize under stringent conditions to a nucleic acid molecule having a nucleotide sequence of only A residues or of only T residues.
An isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence selected from the group consisting of:
- (a) the polypeptide shown as SEQ ID NO:Y or the polypeptide encoded by the cDNA;
- (b) a polypeptide fragment of SEQ ID NO:Y or the polypeptide encoded by the cDNA;
- (c) a polypeptide epitope of SEQ ID NO:Y or the polypeptide encoded by the cDNA;
- and
- (d) a variant of SEQ ID NO:Y.
Dependencies are inferred from the claim text.