Antimicrobial and anti-inflammatory peptides
AssigneeMicrologix Biotech Inc.
InventorsPatricia J. McNicol, Sonia K. Pawlak, Evelina Rubinchik, Dale Cameron, Maria Marta Guarna
Life of this patent
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Abstract
Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.
Claims25
An indolicidin analog of up to 35 amino acids, comprising one of the following sequences:
- 11B11, 11B24, 11B38, 11D21, 11F11, 11F35, 11F43, 11F46, 11F60, 11F61, 11F65, 11F82, 11F83, 11F110, 11J32, 11J33, 11J37, 11J44, 11J45, 11J84, 11J97, 11J105, 11J115, 11J131, 11J136, 11J148, or 11J157.
A composition comprising a viscosity-increasing agent, a solvent, and an indolicidin analog of up to 35 amino acids, comprising one of the following sequences:
- 11B7, 11B11, 11B24, 11B38, 11D21, 11F4, 11F11, 11F12, 11F17, 11F35, 11F43, 11F46, 11F60, 11F61, 11F65, 11F66, 11F82, 11F83, 11F110, 11J02, 11J30, 11J32, 11J33, 11J37, 11J44, 11J45, 11J67, 11J68, 11J84, 11J97, 11J105, 11J115, 11J131, 11J136, 11J148, or 11J157.
A composition comprising a buffering agent, a solvent, and an indolicidin analog of up to 35 amino acids, comprising one of the following sequences:
- 11B7, 11B11, 11B24, 11B38, 11D21, 11F4, 11F11, 11F12, 11F17, 11F35, 11F43, 11F46, 11F60, 11F61, 11F65, 11F66, 11F82, 11F83, 11F110, 11J02, 11J30, 11J32, 11J33, 11J37, 11J44, 11J45, 11J67, 11J68, 11J84, 11J97, 11J105, 11J115, 11J131, 11J136, 11J148, or 11J157.
A method for treating or preventing inflammation at a target site, comprising applying to the target site an indolicidin analog of up to 35 amino acids, comprising one of the following sequences:
- 11B7, 11B11, 11B24, 11B38, 11D21, 11F4, 11F11, 11F12, 11F17, 11F35, 11F43, 11F46, 11F60, 11F61, 11F65, 11F66, 11F82, 11F83, 11F110, 11J02, 11J30, 11J32, 11J33, 11J37, 11J44, 11J45, 11J67, 11J68, 11J84, 11J97, 11J105, 11J115, 11J131, 11J136, 11J148, or 11J157.
A method for ameliorating inflammation at a target site, comprising applying to the target site an indolicidin analog of up to 35 amino acids, comprising one of the following sequences:
- 11B7, 11B11, 11B24, 11B38, 11D21, 11F4, 11F11, 11F12, 11F17, 11F35, 11F43, 11F46, 11F60, 11F61, 11F65, 11F66, 11F82, 11F83, 11F110, 11J02, 11J30, 11J32, 11J33, 11J37, 11J44, 11J45, 11J67, 11J68, 11J84, 11J97, 11J105, 11J115, 11J131, 11J136, 11J148, or 11J157.
A method for treating or preventing inflammation at a target site, comprising applying to the target site a composition comprising a viscosity-increasing agent, a solvent, and an indolicidin analog of up to 35 amino acids, comprising one of the following sequences:
- 11B7, 11B11, 11B24, 11B38, 11D21, 11F4, 11F11, 11F12, 11F17, 11F35, 11F43, 11F46, 11F60, 11F61, 11F65, 11F66, 11F82, 11F83, 11F110, 11J02, 11J30, 11J32, 11J33, 11J37, 11J44, 11J45, 11J67, 11J68, 11J84, 11J97, 11J105, 11J115, 11J131, 11J136, 11J148, or 11J157.
A method for ameliorating inflammation at a target site, comprising applying to the target site a composition comprising a viscosity-increasing agent, a solvent, and an indolicidin analog of up to 35 amino acids, comprising one of the following sequences:
- 11B7, 11B11, 11B24, 11B38, 11D21, 11F4, 11F11, 11F12, 11F17, 11F35, 11F43, 11F46, 11F60, 11F61, 11F65, 11F66, 11F82, 11F83, 11F110, 11J02, 11J30, 11J32, 11J33, 11J37, 11J44, 11J45, 11J67, 11J68, 11J84, 11J97, 11J105, 11J115, 11J131, 11J136, 11J148, or 11J157.
A method for treating, preventing, or ameliorating inflammation, comprising administering parenterally a composition comprising a buffering agent, a solvent, and an indolicidin analog of up to 35 amino acids, comprising one of the following sequences:
- 11B7, 11B11, 11B24, 11B38, 11D21, 11F4, 11F11, 11F12, 11F17, 11F35, 11F43, 11F46, 11F60, 11F61, 11F65, 11F66, 11F82, 11F83, 11F110, 11J02, 11J30, 11J32, 11J33, 11J37, 11J44, 11J45, 11J67, 11J68, 11J84, 11J97, 11J105, 11J115, 11J131, 11J136, 11J148, or 11J157.
Dependencies are inferred from the claim text.