Novel nuclear factor polypeptides and nucleic acids encoding same
OwnerJohn A. Peyman, John Carulli +1inventors
InventorsJohn A. Peyman, John Carulli, Jeffrey L. Browning
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Abstract
The present invention provides PNF1, a novel isolated polypeptide, as well as a polynucleotide encoding PNF1 and antibodies that immunospecifically bind to PNF1 or any derivative, variant, mutant, or fragment of the PNF1 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the PNF1 polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.
Claims43
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) a mature form of the amino acid sequence given by SEQ ID NO:2;
- b) a variant of a mature form of the amino acid sequence given by SEQ ID NO:2, wherein any amino acid in the mature form is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence of the mature form are so changed;
- c) the amino acid sequence given by SEQ ID NO:2;
- d) a variant of the amino acid sequence given by SEQ ID NO:2 wherein any amino acid specified in the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence are so changed;
- and
- e) a fragment of any of a) through d).
An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) a mature form of the amino acid sequence given SEQ ID NO:2;
- b) a variant of a mature form of the amino acid sequence given by SEQ ID NO:2 wherein any amino acid in the mature form of the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence of the mature form are so changed;
- c) the amino acid sequence given by SEQ ID NO:2;
- d) a variant of the amino acid sequence given by SEQ ID NO:2, in which any amino acid specified in the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence are so changed;
- e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising the amino acid sequence given by SEQ ID NO:2 or any variant of said polypeptide wherein any amino acid of the chosen sequence is changed to a different amino acid, provided that no more than 10% of the amino acid residues in the sequence are so changed;
- and
- f) the complement of any of said nucleic acid molecules.
A method of treating a pathological state in a mammal, the method comprising administering to the mammal a polypeptide in an amount that is sufficient to alleviate the pathological state, wherein the polypeptide is a polypeptide having an amino acid sequence at least 95% identical to a polypeptide comprising the amino acid sequence given by SEQ ID NO:2 or a biologically active fragment thereof.
Dependencies are inferred from the claim text.