Medium containing flt3 ligand for culturing hematophoietic cells
AssigneeImmunex Corporation
InventorsSTEWART D. LYMAN, M. PATRICIA BECKMANN
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Abstract
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3 -L finds use in treating patients with anemia, AIDS and various cancers.
Claims2
A hematopoietic cell expansion media comprising cell growth media, and flt3-L alone or in combination with a cellular growth factor, wherein the flt3-L and the growth factor are in an amount sufficient to cause hematopoietic cell expansion.
A method for expanding hematopoietic cells comprising contacting the cells with flt3-L alone or in combination with a cellular growth factor, wherein the flt3-L and the growth factor are in an amount sufficient to cause hematopoietic cell expansion.
Dependencies are inferred from the claim text.