Generation of hematopoietic cells from multipotent neutral stem cells
AssigneeNeurosoheres Holdings Ltd.
InventorsChristopher R. Bjornson, Rod L. Rietze, Brent A. Reynolds, Angelo L. Vescovi
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Abstract
Multipotent neural stem cell (MNSC) progeny are induced to generate cells of the hematopoietic system by placing the MNSC progeny in a hematopoietic-inducing environment. The hematopoietic-inducing environment can be either ex vivo or in vivo. A mammal's circulatory system provides an in vivo environment that can induce xenogeneic, allogeneic, or autologous MNSC progeny to generate a full complement of hematopoietic cells. Transplantation of MNSC progeny provides an alternative to bone marrow and hematopoietic stem cell transplantation to treat blood-related disorders.
Claims4
A method of generating hematopoietic cells from mammalian multipotent neural stem cell progeny comprising in an environment that induces said multipotent neural stem cell progeny to produce said hematopoietic cells, wherein said environment comprises a mammal and said multipotent neural stem cell progeny are administered to said mammal.
Dependencies are inferred from the claim text.