Crystal structure of a MarR family polypeptide
AssigneesTrustees of Tufts College, Trustees of Boston University
InventorsMichael N. Alekshun, Stuart B. Levy, James F. Head, Barbara A. Seaton
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Abstract
The crystal structure of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, is described.
Claims29
A crystallized MarR family polypeptide, wherein said crystallized MarR family polypeptide is crystallized under appropriate conditions such that the three dimensional structure of said MarR family polypeptide can be determined.
A crystallized MarR family polypeptide defined by the atomic coordinates given in FIG. 7.
A crystallized MarR family polypeptide defined by the atomic coordinates given in FIG. 8.
A method for determining the three dimensional structure of MarR family polypeptide, comprising
- crystallizing the MarR family polypeptide under appropriate conditions such that crystals are formed;
- and
- analyzing the crystallized MarR family polypeptide, such that the three dimensional structure of the MarR family polypeptide is determined.
A method of making a crystal of a MarR family polypeptide comprising:
- contacting MarR with a modulator to form a complex and allowing crystals of the complex to grow.
Dependencies are inferred from the claim text.