Method for kinetic resolution of racemates of alcohols having one or several stereogenic centers

Abstract

The present intention relates to a method for kinetic resolution of racemates of alcohols with one or several stereogenic centers. The invention is particularly suitable for producing pharmaceutical agents or plant protective agents. According to the invention, first racemic alcohols are converted with fluorinated acylation agents into racemic fluorinated carboxylic acid esters. Subsequently, by lipase-catalyzed reaction of the racemic fluorinated carboxylic acid ester with alcohols the fluorous phase marking of the faster reacting enantiomer is canceled and that of the slower reacting enatiomer is maintained. Subsequently, the enantiomers are extractively separated by distribution between organic phase and fluorous phase.

Dependencies are inferred from the claim text.