Mutant N-acetylglutamate synthase and method for L-arginine production
AssigneeAjinomoto Co., Inc.
InventorsLeonid Romanovich Ptitsyn, Irina Borisovna Altman, Sergey Vasil?apos;evich Smirnov, Yulia Georgievna Rostova, Tatyana Abramovna Yampolskaya, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner
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Abstract
L-arginine is produced using a bacterium belonging to the genus Escherichia harboring a mutant N-acetylglutamate synthase in which the amino acid sequence corresponding to positions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized.
Claims6
A mutant N-accetylglutamate synthase wherein the amino acid sequence corresponding to postitions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS:
- 1 to 4, and feedback inhibition by L-arginine is desensitized.
Dependencies are inferred from the claim text.