New mutant glutamine synthetase and method for producing amino acids
AssigneeAjinomoto Co., Inc.
InventorsMikhail Markovich Gusyatiner, Lirina Valerievna Ivanovskaya, Tatyana Viktorovna Leonova, Ekaterina Igorevna Mukhanova, Yulia Georgievna Rostova, Dmitriy Vladimirovich Filippov, Daria Aleksandrovna Chudakova
Life of this patent
Estimating the term…
Abstract
Amino acids, such as L-glutamine, L-arginine, L-tryptophan, L-histidine and L-glutamate are produced using a bacterium belonging to the genus Escherichia harboring a mutant glutamine synthetase in which the tyrosine amino acid residue corresponding to position 397 in a wild type glutamine synthetase is replaced with any of amino acid residues, preferably with phenylalanine.
Claims13
A glutamine synthetase comprising amino acid sequence shown in SEQ ID NO:
- 1 in Sequence listing, wherein the tyrosine residue corresponding to the position 397 of SEQ ID NO:
- 1 is replaced with an amino acid residue other than tyrosine residue.
Dependencies are inferred from the claim text.