Interleukin-1 homolog zil1a4
AssigneeZymoGenetics, Inc.
InventorsRobert R. West, Paul O. Sheppard, Zeren Gao
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Abstract
Homologs of interleukin-1, materials and methods for making them, compositions comprising them, and methods of using them are disclosed. The invention includes polypeptides comprising residues 60 through 218 of SEQ ID NO:7 or residues 1 through 157 of SEQ ID NO:10. Polypeptides and polynucleotides of the invention are useful within diagnostic, therapeutic, and analytical fields, including modulation of immune responses.
Claims21
An isolated protein comprising a sequence of amino acid residues selected from the group consisting of:
- residues 60 through 218 of SEQ ID NO:7;
- and
- residues 1 through 157 of SEQ ID NO:10.
An isolated polynucleotide encoding a protein comprising a sequence of amino acid residues selected from the group consisting of:
- residues 60 through 218 of SEQ ID NO:7;
- and
- residues 1 through 157 of SEQ ID NO:10.
An expression vector comprising the following operably linked elements:
- (a) a transcription promoter;
- (b) a DNA segment encoding a protein comprising a sequence of amino acid residues selected from the group consisting of residues 60 through 218 of SEQ ID NO:7 and residues 1 through 157 of SEQ ID NO:10;
- and
- (c) a transcription terminator.
A method of modulating an immune response in an animal comprising administering to said animal a composition comprising a protein in combination with a pharmaceutically acceptable vehicle, wherein said protein comprises a sequence of amino acid residues selected from the group consisting of:
- residues 60 through 218 of SEQ ID NO:7;
- and
- residues 1 through 157 of SEQ ID NO:10.
Dependencies are inferred from the claim text.