Novel G-protein coupled receptor, HLTEX11
AssigneeSmithKline Beecham Corporation
InventorsWinnie Chan, Derk J. Bergsma, Catherine E. Ellis
Life of this patent
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Abstract
Human HL TEX11 polypeptides and DNA (RNA) encoding such HL TEX11 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HL TEX11 for the treatment of atherosclerosis. inflammatory conditions. and infections. particularly viral infections such as AIDS. among others, among others. are also disclosed. Also disclosed are diagnostic assavs for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HL TEX11 and for detecting altered levels of the polypeptide in a host.
Claims22
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide having at least a 70% identity to a polynucleotide encoding a polypeptide comprising amino acids 1 to 339 of SEQ ID NO:
- 2:
- (b) a polynucleotide which by virrue of the redundancy of the genetic code, encodes the same amino acids of SEQ ID NO:
- 2:
- (c) a polynucleotide which is complementary, to the polynucleotide of (a) or (b);
- and
- (d) a polynrucleotide comprising at least 15 contiguous bases of the polynucleotide of (a), (b) or (c).
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide having at least a 70% identity to a polynucleotide encoding the same mature polypeptide expressed by the human cDNA contained in ATCC Deposit No. 98130;
- (b) a polynucleotide which by virtue of the redundancy of the genetic code encodes the same mature polypeptide expressed by the human cDNA contained in ATCC Deposit No. 98130;
- (c) a polynucleotide complementary to the polynucleotide of (a) or (b):
- and
- (d) a polynucleotide comprising at least 15 contiguous bases of the polynucleotide of (a), (b) or (c).
A polypeptide comprising an amino acid sequence which is at least 70% identical to amino acid 1 to 339 of SEQ ID NO:
- 2.
A polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:
Dependencies are inferred from the claim text.