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AssigneePresident and Fellows of Harvard College
InventorsMarc W. Kirschner, Olaf Stemmann, Hui Zou, Steven P. Gygi
Estimating the term…
The invention provides nucleic acid molecules, designated separase nucleic acid molecules, which encode separase, an endopeptidase that modulates sister chromatid separation. The invention also provides recombinant expression vectors containing separase nucleic acid molecules and host cells into which the expression vectors have been introduced. The invention still further provides separase proteins, fusion proteins, antigenic peptides and anti-separase antibodies. The invention also provides methods for the identification of modulators of separase, methods of modulating separase, methods of modulating sister chromatid separation, and methods for the treatment of disorders related to aberrant sister chromatid separation, such as cancer, Down's syndrome, and spontaneous fetal abortion.
A nucleic acid molecule which encodes a polypeptide having one or more separase activities, wherein the separase activities are selected from the group consisting of:
A nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence having at least about 60%, 70%, 80%, 90%, 95% or more sequence homology to an amino acid sequence of SEQ ID NO:3, wherein the polypeptide has one or more separase activities.
A nucleic acid molecule comprising a nucleotide sequence having at least 60%, 70%, 80%, 90%, 95% or more sequence homology to a nucleotide sequence of SEQ ID NO:2, wherein the nucleotide sequence encodes a polypeptide having one or more separase activities.
A nucleic acid molecule comprising a nucleotide sequence of SEQ ID NO:2 or analogs thereof.
A nucleic acid molecule consisting essentially of a nucleotide sequence of SEQ ID NO:2 or analogs thereof.
A nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence of SEQ ID NO:3 or analogs thereof.
A nucleic acid molecule which encodes a polypeptide consisting essentially of an amino acid sequence of SEQ ID NO:3 or analogs thereof.
A nucleic acid molecule, selected from the group consisting of:
A polypeptide having one or more separase activities, wherein the separase activities are selected from the group consisting of:
A polypeptide comprising an amino acid sequence having at least about 60%, 70%, 80%, 90%, 95% or more sequence homology to an amino acid sequence of SEQ ID NO:3, wherein the polypeptide has one or more separase activities.
A polypeptide comprising an amino acid sequence of SEQ ID NO:3 or analogs thereof.
A polypeptide consisting essentially of an amino acid sequence of SEQ ID NO:3 or analogs thereof.
A polypeptide selected from the group consisting of:
Dependencies are inferred from the claim text.