Monkey and canine melanin concentrating hormone receptors
AssigneeNeurogen Corporation
InventorsMichele Bennet Kinrade, Robbin M. Brodbeck, Stephen M. Waters, James E. Krause
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Abstract
Isolated polynucleotides encoding monkey and canine Melanin Concentrating Hormone (MCH) Type 2 receptors and chimeric polypeptides are provided. Vectors and cells for recombinant expression of such MCH receptor polypeptides, and isolated MCH receptor polypeptides are also provided. MCH receptor polynucleotides and polypeptides may be used, for example, to identify agents that specifically interact with MCH receptor. Such agents find use within therapies for humans and animals afflicted with conditions associated with MCH receptor activation.
Claims16
An MCH2R chimeric polypeptide, comprising a cynomolgus macaque sequence recited in SEQ ID NO:2 or SEQ ID NO:4 wherein the intracellular loop 3, N-terminal domain and/or C-terminal domain is replaced with a corresponding domain of MCH1R, NPY1 receptor, beta-2-adrenergic receptor, human MCH2R or canine MCH2R.
Dependencies are inferred from the claim text.