Sweet taste receptors

An isolated or recombinant polypeptide that comprises one or more of the following:

• (a.) an amino acid sequence or subsequence that is at least 75% identical to SEQ ID NO. 1, SEQ ID NO.4, or SEQ ID NO.7 as determined by BLASTP using default parameters;
• (b.) an amino acid sequence or subsequence that comprises one or more domains of an hT1R1 polypeptide, an hT1R2 polypeptide, or an hT1R3 polypeptide, wherein the hT1R1 polypeptide, the hT1R2 polypeptide, or the hT1R3 polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO. 1, SEQ ID NO.4 and SEQ ID NO.7;
• (c.) an amino acid sequence or subsequence that is at least 75% identical to a domain encoded by SEQ ID NO. 1, SEQ ID NO.4 or SEQ ID NO.7 as determined by BLASTP using default parameters, wherein the domain is selected from the group consisting of:
• an amino-terminal extracellular domain;
• an extracellular domain located between TM2 and TM3, between TM4 and TM5, or between TM6 and TM7;
• a transmembrane (TM) domain;
• an intracellular domain located between TM1 and TM2, between TM3 and TM4, or between TM5 and TM6;
• and a carboxyl-terminal intracellular domain;
• (d.) an amino acid sequence or subsequence that is specifically bound by an antibody that specifically binds to an amino acid selected from the group consisting of SEQ ID NO. 1, SEQ ID NO.4, and SEQ ID NO.7, wherein the antibody is not specifically bound by an amino acid selected from the group consisting of SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO.5, SEQ ID NO.6, SEQ ID NO.8, and SEQ ID NO.9;
• (e.) an amino acid sequence or subsequence that is encoded by SEQ ID NO. 10, SEQ ID NO. 11, SEQ ID NO 12, or a complementary sequence thereof;
• (f.) an amino acid sequence or subsequence that is encoded by a first nucleic acid that specifically hybridizes to a second nucleic acid, wherein the second nucleic acid is selected from the group consisting of:
• SEQ ID NO. 10, SEQ ID NO. 11, SEQ ID NO 12, or a complement thereof, under stringent conditions, wherein the first nucleic acid hybridizes to the second nucleic acid under said stringent conditions with at least 5× an affinity that the first nucleic acid hybridizes to a third nucleic acid selected from the group consisting of:
• an mT1R1 nucleic acid, an rT1R1 nucleic acid, an mT1R2 nucleic acid, an rT1R2 nucleic acid, an mT1R3 nucleic acid and a rT1R3 nucleic acid;
• or,
• (g.) an amino acid-sequence or subsequence corresponding to a conservative variation an amino acid sequence or subsequence of any one of (a.)-(f.).