Sodium-independent small neutral amino acid transporters transporting L- and D-amino acids and genes thereof
AssigneeJapan Science and Technology Corporation, Japan
InventorsHitoshi Endou, Yoshikatsu Kanai
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Abstract
Novel sodium-independent small neutral amino acid transporters which transport L- and D-amino acids. A protein comprising the amino acid sequence represented by SEQ ID NO:1 or 4 or an amino acid derived therefrom by deletion, substitution or addition of one or more amino acids and being capable of sodium-independently transporting L- and D-small neutral amino acids and analogs thereof; a gene encoding the above protein; a method of screening substances inhibiting or promoting the function of the above protein; an antibody against the above protein; and a method of regulating cell function by using the above antibody, function inhibitors, function promoters, etc.
Claims22
Protein which comprises an amino acid sequence represented by SEQ ID NO:
- 1 or 4 or an amino acid sequence where one or more amino acid(s) is/are deleted, substituted or added in the said amino acid sequence and which is capable of transporting a small neutral amino acid or analog thereof in a sodium-independent manner.
Gene coding for protein which comprises a base sequence represented by SEQ ID NO:
- 2 or 5 or a base sequence hybridizable to DNA comprising the said base sequence under a stringent condition and which is capable of transporting a small neutral amino acid or analog thereof in a sodium-independent manner.
Nucleotide containing a partial sequence of 14 or more bases in the base sequence represented by SEQ ID NO:
- 2 or 5 or containing a sequence complementary thereto.
Dependencies are inferred from the claim text.