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US 2003/0148410 A1Published application
Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer
AssigneeMillennium Pharmaceuticals, Inc.
InventorsAllison Berger, Tracy L. Guillemette, Robert Schlegel, John E. Monahan, Shubhangi Kamatkar, Stephen N. Thibodeau, Lawrence J. Burgart
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Abstract
The invention relates to newly discovered nucleic acid molecules and proteins associated with colon cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human colon cancers are provided.
Claims5
An isolated nucleic acid molecule comprising a nucleotide sequence of SEQ ID NOS:
- 1, 3, 25, 38, 56, 102, 104, 106, 135, 156, 158, 164, 166, 190, 218, 219, 225 or 227.
A method of assessing whether a patient is afflicted with colon cancer, the method comprising:
- a) determining the level of expression of a marker in a patient sample, wherein the marker is selected from the group consisting of the markers of Table 1;
- and
- b) determining the normal level of expression of the marker in a control non-colon cancer sample,
- wherein a significant increase in the level of expression of the marker in the patient sample compared to the level of expression of the marker in the control sample is an indication that the patient is afflicted with colon cancer.
1 more element
An isolated polypeptide comprising the amino acid sequence of SEQ ID NOS:
- 4, 103, 134, 136, 157, 220, 226 or 228.
Dependencies are inferred from the claim text.