Direct targeting binding proteins
OwnerEdmund Rossi, Chien-Hsing Ken Chang +1inventors
InventorsEdmund Rossi, Chien-Hsing Ken Chang, David M. Goldenberg
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Abstract
The present invention relates to multivalent, monospecific binding proteins. These binding proteins comprise two or more binding sites, where each binding site specifically binds to the same type of target cell, and preferably with the same antigen on such a target cell. The present invention further relates to compositions of monospecific diabodies, triabodies, and tetrabodies, and to recombinant vectors useful for the expression of these functional binding proteins in a microbial host. Also provided are methods of using invention compositions in the treatment and/or diagnosis of tumors.
Claims57
A multivalent, monospecific binding protein comprising two or more binding sites having affinity for the same single target antigen, wherein said binding sites are formed by the association of two or more single chain Fv (scFv) fragments, and wherein each scFv fragment comprises at least 2 variable domains derived from a humanized or human monoclonal antibody.
A multivalent, monospecific binding protein comprising two binding sites having affinity for the same single target antigen (termed a monospecific diabody), wherein said binding sites are formed by the association of two single chain Fv (scFv) fragments, and wherein each scFv fragment comprises at least 2 variable domains derived from a humanized or human monoclonal antibody.
A multivalent, monospecific binding protein comprising three binding sites having affinity for the same single target antigen (termed a monospecific triabody), wherein said binding sites are formed by the association of three single chain Fv (scFv) fragments, and wherein each scFv fragment comprises at least 2 variable domains derived from a humanized or human monoclonal antibody.
A multivalent, monospecific binding protein comprising four binding sites having affinity for the same single target antigen (termed a monospecific tetrabody), wherein said binding sites are formed by the association of four single chain Fv (scFv) fragments, and wherein each scFv fragment comprises at least 2 variable domains derived from a humanized or human monoclonal antibody.
Dependencies are inferred from the claim text.