Back to results
US 2003/0148408 A1Published application
Compositions and methods for the diagnosis and treatment of tumor
AssigneeGenentech, Inc.
InventorsGretchen Frantz, Kenneth J. Hillan, Heidi Phillips, Paul Polakis, Susan D. Spencer, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
Life of this patent
Estimating the term…
Abstract
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
Claims15
An isolated antibody that binds to a polypeptide having at least 80% amino acid sequence identity to:
- (a) the polypeptide shown in any one of FIGS. 57-112, 114, 116, 118 or 120 (SEQ ID NOS:57-112, 114, 116, 118 or 120);
- (b) the polypeptide shown in any one of FIGS. 57-112, 114, 116, 118 or 120 (SEQ ID NOS:57-112, 114, 116, 118 or 120), lacking its associated signal peptide;
- (c) an extracellular domain of the polypeptide shown in any one of FIGS. 57-112, 114, 116, 118 or 120 (SEQ ID NOS:57-112, 114, 116, 118 or 120), with its associated signal peptide;
- (d) an extracellular domain of the polypeptide shown in any one of FIGS. 57-112, 114, 116, 118 or 120 (SEQ ID NOS:57-112, 114, 116, 118 or 120), lacking its associated signal peptide;
- (e) a polypeptide encoded by the nucleotide sequence shown in any one of FIGS. 1-56, 113, 115, 117 or 119 (SEQ ID NOS:1-56, 113, 115, 117 or 119);
- or
- (f) a polypeptide encoded by the full-length coding region of the nucleotide sequence shown in any one of FIGS. 1-56, 113, 115, 117 or 119 (SEQ ID NOS:1-56, 113, 115, 117 or 119).
4 more elements
An isolated antibody that binds to a polypeptide having:
- (a) the amino acid sequence shown in any one of FIGS. 57-112, 114, 116, 118 or 120 (SEQ ID NOS:57-112, 114, 116, 118 or 120);
- (b) the amino acid sequence shown in any one of FIGS. 57-112, 114, 116, 118 or 120 (SEQ ID NOS:57-112, 114, 116, 118 or 120), lacking its associated signal peptide sequence;
- (c) an amino acid sequence of an extracellular domain of the polypeptide shown in any one of FIGS. 57-112, 114, 116, 118 or 120 (SEQ ID NOS:57-112, 114, 116, 118 or 120), with its associated signal peptide sequence;
- (d) an amino acid sequence of an extracellular domain of the polypeptide shown in any one of FIGS. 57-112, 114, 116, 118 or 120 (SEQ ID NOS:57-112, 114, 116, 118 or 120), lacking its associated signal peptide sequence;
- (e) an amino acid sequence encoded by the nucleotide sequence shown in any one of FIGS. 1-56, 113, 115, 117 or 119 (SEQ ID NOS:1-56, 113, 115, 117 or 119);
- or
- (f) an amino acid sequence encoded by the full-length coding region of the nucleotide sequence shown in any one of FIGS. 1-56, 113, 115, 117 or 119 (SEQ ID NOS:1-56, 113, 115, 117 or 119).
4 more elements
Dependencies are inferred from the claim text.