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OwnerZairen Sun, Wufang Fan +3inventors
InventorsZairen Sun, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are modulated during angiogeneis and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, determining predisposition to, etc., diseases and conditions, such as abnormal, insufficient, excessive, etc., angiogenesis, inflammatory diseases, rheumatoid arthritis, osteoarthritis, asthma, pulmonary fibrosis, age-related macular degeneration (ARMD), diabetic retinopathy, macular degeneration, and retinopathy of prematurity (ROP), endometriosis, cancer, Coats' disease, peripheral retinal neovascularization, neovascular glaucoma, psoriasis, retrolental fibroplasias, angiofibroma, inflammation, etc.
An isolated polynucleotide comprising a polynucleotide sequence which codes without interruption for human ANH401 having the amino acid sequence set forth in SEQ ID NO 2, or a complement thereto.
An isolated human ANH401 polynucleotide comprising,
An isolated human ANH401 polypeptide comprising an amino acid sequence having 99% or more sequence identity to the amino acid sequence set forth in SEQ ID NO 2, and which has NADP binding activity.
Dependencies are inferred from the claim text.