Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
AssigneeSmithKline Beecham Corporation
InventorsColin H. MacPhee, David Graham Tew
Life of this patent
Estimating the term…
Abstract
The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compunds to identify those compounds.
Claims24
The enzyme Lp-PLA2 in purified form.
An enzyme fragment selected from SEQ.ID NOs:1, 2, 3, 4, 10 and 11.
An isolated nucleic acid molecule encoding Lp-PLA2 or an antisense analogue thereof.
The use of an inhibitor of the enzyme Lp-PLA2 in therapy.
The use of an inhibitor of Lp-PLA2 in the treatment of atherosclerosis
A method of diagnosis of a patients susceptibility to atherosclerosis which comprises taking a sample of blood from the patient and analysing said sample for the presence of the enzyme Lp-PLA2.
A method of screening compounds to identify those compunds which inhibit the enzyme comprising contacting isolated enzyme Lp-PLA2 with a test compound and measuring the rate of turnover of an enzyme substrate as compared with the rate of turnover in the absence of test compound.
Dependencies are inferred from the claim text.