Schizophrenia related gene and protein
AssigneeGenset S.A.
InventorsBernard Bihain, Barbara Bour, Lydie Bougueleret
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Abstract
The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns methods for the treatment or diagnosis of schizophrenia, bipolar disorder or related CNS disorder. The invention also concerns the interaction of PAPAP with schizophrenia candidate gene g34872.
Claims13
An isolated, purified or recombinant polynucleotide encoding the PAPAP polypeptide of SEQ ID No 2.
An isolated, purified or recombinant polynucleotide comprising the nucleotide sequence of SEQ ID No. 1 or the complement thereof.
A purified or isolated PAPAP polypeptide encoded by the nucleotide sequence of SEQ ID No 1.
A purified or isolated PAPAP polypeptide comprising the amino acid sequence of SEQ ID No 2.
A method for the screening of a candidate substance, said method comprising:
- a) cultivating a prokaryotic or a eukaryotic cell that has been transfected with a nucleotide sequence encoding a PAPAP protein, placed under the control of its own promoter;
- b) bringing into contact the cultivated cell with said candidate molecule;
- c) detecting the expression of said PAPAP protein in the presence of said candidate molecule.
Dependencies are inferred from the claim text.