Vitro model for priocidal activity
AssigneeSTERIS Inc.
InventorsKathleen M. Antloga, Gerald E. McDonnell
Life of this patent
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Abstract
A proteinaceous material has been found to show similar activity and treatment response to that of disease causing prions, such as CJD. A prion model which incorporates the proteinaceous material has a variety of applications. The model has an ability to be cultured either in vivo or in vitro, allowing rapid screening of potential drugs for treating animals or humans, or methods of treating food products or items which may come into contact with prions, such as medical or dental devices. Several treatment methods and materials have been developed using the model.
Claims20
A method for evaluating potential treatments for activity against prions or prion-related diseases, comprising:
- subjecting a prion model to the treatment, the prion model being one which has been shown to exhibit a response similar to that of prions to a treatment designed to attack prions;
- and
- evaluating the effect of the treatment on the prion model as an indicator of the effect of the treatment on the prion or prion-related disease.
A method of treating an item which may be contaminated with prions, the method comprising:
- treating the item with a composition which includes at least one of nisin, manganese, and silver nitrate to reduce the level of viable prions on the item.
A method of screening proposed drugs for activity against prion related diseases or proposed treatment processes or chemicals for priocidal activity comprising:
- exposing a prion model to the proposed drug, chemical, or process;
- and
- culturing any remaining prion model in vitro, the prion model having been shown to exhibit similar responses to prions to a drug, chemical, or process.
A method of treating a subject having a prion related disease comprising:
- treating a sample contaminated with an IFDO with a proposed treatment agent, the IFDO having been shown to respond to other treatment agents in a similar manner to the prion;
- if the treatment agent is effective at attacking the IFDO, treating the subject with the treatment agent in an effective amount.
Dependencies are inferred from the claim text.