Phosphodiesterase 10
AssigneeICOS Corporation
InventorKate Loughney
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Abstract
The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE10, and more particularly, binding partners that modulate PDE10 enzyme activity.
Claims33
A purified and isolated PDE10 polypeptide.
A polynucleotide comprising the sequence set out in SEQ ID NO:
- 1 or a fragment thereof.
A polynucleotide comprising the sequence set out in SEQ ID NO:
- 18 or a fragment thereof.
A polynucleotide comprising the sequence set out in SEQ ID NO:
- 20 or a fragment thereof.
A polynucleotide comprising the sequence set out in SEQ ID NO:
- 22 or a fragment thereof.
Dependencies are inferred from the claim text.