Complementary peptide ligands generated from plant genomes
OwnerGareth W. Roberts, Jonathan R. Healinventors
Life of this patent
Estimating the term…
Abstract
In the current invention the application of our novel informatics approach to the databases containing nucleotide and peptide sequences from plant genomes generates the sequence of many peptides which form the basis of an innovative and novel approach to developing new therapeutic agents. This invention claims the use of specific complementary peptides to the proteins encoded in the genomes of plants as reagents for agricultural discovery programmes.
Claims19
A set of peptide ligands;
- said set consisting of specific complementary peptides to proteins encoded by genes of plant genomes.
A novel peptide having a sequence which is a member of a set according to any preceding claim, capable of antagonising or agonising a specific interaction of a protein with another protein or receptor.
A method for processing sequence data comprising the steps of:
- selecting a first protein sequence and a second protein sequence;
- selecting a frame size corresponding to a number of sequence elements such as amino acids or triplet codons, a score threshold, and a frame existence probability threshold;
- comparing each frame of the first sequence with each frame of the second sequence by comparing pairs of sequence elements at corresponding positions within each such pair of frames to evaluate a complementary relationship score for each pair of frames;
- storing details of any pairs of frames for which the score equals or exceeds the score threshold;
- evaluating for each stored pair of frames the probability of the existence of that complementary pair of frames existing, on the basis of the number of possible complementary sequence elements existing for each sequence element in the pair of frames;
- and
- discarding any stored pairs of frames for which the evaluated probability is greater than the probability threshold;
- wherein each frame is a peptide sequence of defined length.
A method according to any preceding claim, in which the sequence elements are amino acids and pairs of amino acids are compared by using an antisense score list.
A method for processing sequence data substantially as described herein with reference to FIGS. 1 to 6.
Dependencies are inferred from the claim text.