Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins,and uses thereof
OwnerMing-Hui Wei, Marion Webster +3inventors
InventorsMing-Hui Wei, Marion Webster, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
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Abstract
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
Claims23
An isolated peptide consisting of an amino acid sequence selected from the group consisting of:
- (a) an amino acid sequence shown in SEQ ID NO:
- 2;
- (b) an amino acid sequence of an allelic variant of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said allelic variant is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:
- 1 or 3;
- (c) an amino acid sequence of an ortholog of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said ortholog is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:
- 1 or 3;
- and
- (d) a fragment of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said fragment comprises at least 10 contiguous amino acids.
An isolated peptide comprising an amino acid sequence selected from the group consisting of:
- (a) an amino acid sequence shown in SEQ ID NO:
- 2;
- (b) an amino acid sequence of an allelic variant of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said allelic variant is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:
- 1 or 3;
- (c) an amino acid sequence of an ortholog of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said ortholog is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:
- 1 or 3;
- and
- (d) a fragment of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said fragment comprises at least 10 contiguous amino acids.
An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence that encodes an amino acid sequence shown in SEQ ID NO:
- 2;
- (b) a nucleotide sequence that encodes of an allelic variant of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:
- 1 or 3;
- (c) a nucleotide sequence that encodes an ortholog of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:
- 1 or 3;
- (d) a nucleotide sequence that encodes a fragment of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said fragment comprises at least 10 contiguous amino acids;
- and
- (e) a nucleotide sequence that is the complement of a nucleotide sequence of (a)-(d).
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence that encodes an amino acid sequence shown in SEQ ID NO:
- 2;
- (b) a nucleotide sequence that encodes of an allelic variant of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:
- 1 or 3;
- (c) a nucleotide sequence that encodes an ortholog of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS:
- 1 or 3;
- (d) a nucleotide sequence that encodes a fragment of an amino acid sequence shown in SEQ ID NO:
- 2, wherein said fragment comprises at least 10 contiguous amino acids;
- and
- (e) a nucleotide sequence that is the complement of a nucleotide sequence of (a)-(d).
An isolated human transporter peptide having an amino acid sequence that shares at least 70% homology with an amino acid sequence shown in SEQ ID NO:
- 2.
An isolated nucleic acid molecule encoding a human transporter peptide, said nucleic acid molecule sharing at least 80 percent homology with a nucleic acid molecule shown in SEQ ID NOS:
- 1 or 3.
Dependencies are inferred from the claim text.