Anti-bacterial methods and materials
OwnerDavid Holden, Ji Min Meiinventors
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Abstract
Staphylococcus aureus virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel S. aureus mutants useful in vaccines.
Claims14
A method of identifying an anti-bacterial agent comprising the steps of assaying potential agents for the ability to interfere with expression of virulence gene products represented by the DNA sequences set forth in any one of SEQ ID NOS:
- 1 through 94, and identifying an agent that interferes with expression of said virulence gene products.
A method of identifying an anti-bacterial agent comprising the steps of assaying potential agents for the ability to interfere with the function of a bacterial protein encoded in whole or in part by a DNA sequence set forth in any one of SEQ ID NOS:
- 1 through 94 or the complementary strand thereof, and identifying an agent that interferes with the function of said bacterial protein.
A Staphylococcus aureus organism containing a functional mutation in a gene represented by any one of SEQ ID NOS:
- 1 through 94, said functional mutation resulting in a reduction in virulence of the organism.
Dependencies are inferred from the claim text.