Novel human hepatoma associated protein and the polynucleotide encoding said polypeptide
AssigneeShanghai Cancer Institute
InventorsXintai Zhao, Dafang Wan, Jianren Gu
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Abstract
The invention disclosed a new kind of human protein that associated with hepatoma and the polynucleotide encoding said polypeptide and a process for producing the polypeptide by recombinant methods. It also disclosed the method of applying the polypeptide for the diagnosis and treatment of various kinds of disease, such as cancer. The antagonist of the polypeptide and therapeutic use of the same is also disclosed. In addition, the invention disclosed the use of the same. In addition, the invention refers to the use of polynucleotide encoding said hepatoma associated human protein.
Claims15
An isolated human c63R polypeptide comprising a polypeptide having the amino acid sequence of SEQ ID NO:
- 2, its conservative variants, its active fragments, and its active derivatives.
10 A nucleic acid molecule comprising about 8-100 consecutive nucleotides of the polynucleotide of claim 3.
A method for detecting the carcinomatous change or cancer susceptibility of hepatocytes comprising the steps of:
- detecting whether there is any change of c63R transcript in the hepatocyte sample when compared with the normal c63R transcript, and said change indicating that the hepatocyte has developed cancer or is cancer susceptible;
- or
- detecting whether there is any change of activity of c63R protein in the hepatocyte sample when compared with the normal c63R protein, and said change indicating that the hepatocyte has developed cancer or is cancer susceptible.
A kit for detecting hepatocarcinoma comprising the steps of:
- (1) a pair of primers specifically amplifying human c63R gene, and
- (2) the agents for detecting whether there is any change between the amplification product and the normal c63R gene.
Dependencies are inferred from the claim text.