Diagnosis of diseases associated with metastasis
OwnerAlexander Olek, Christian Piepenbrock +1inventors
InventorsAlexander Olek, Christian Piepenbrock, Kurt Berlin
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Abstract
The present invention relates to the chemically modified genomic sequences of genes associated with metastasis, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with metastasis which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with metastasis.
Claims32
A nucleic acid comprising a sequence at least 18 bases in length of a segment of the chemically pretreated DNA of genes associated with metastasis according to one of the sequences taken from the group of Seq. ID No. 1 to Seq. ID No. 198 and sequences complementary thereto.
A nucleic acid comprising a sequence at least 18 base pairs in length of the chemically pretreated DNA of genes associated with metastasis according to one of the sequences according to one of the genes CD20 (L23418), FN1 (M10905), SDC2 (J04621), ACTG1 (NM—001614), CDH2 (NM—001792), CDH4 (NM—001794), CDW52 (NM—001803), ITGAX (NM—000887), NM—002211, ITGB5 (NM—002213), ITGB7 (NM—000889), NEOI (NM—002499), PCDH1 (NM—002587), ENPPI (NM—006208), RTNI (NM—021136), SELPLG (NM—003006), TM4sf2 (NM—004615), ITGEA (NM—002208), SPTB (NM—000347), ITGB1 (NM—002211) and sequences complementary thereto.
A DNA- and/or PNA-array for analyzing diseases associated with the methylation state of genes, comprising at least one nucleic acid according to one of the preceeding claims.
Dependencies are inferred from the claim text.