Human Zven1 proteins
AssigneeZymoGenetics, Inc.
InventorsPaul O. Sheppard, Paul D. Bishop
Life of this patent
Estimating the term…
Abstract
The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
Claims27
An isolated polypeptide comprising an amino acid sequence that is at least 70%, identical to amino acid residues 23 to 108 of SEQ ID NO:2, wherein the isolated polypeptide can specifically bind with an antibody that specifically binds with a polypeptide consisting of the amino acid sequence of SEQ ID NO:2.
An isolated nucleic acid molecule selected from the group consisting of (a) a nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:2, or (b) a nucleic acid molecule that remains hybridized following stringent wash conditions to a nucleic acid molecule consisting of the nucleotide sequence of nucleotides 66 to 161 of SEQ ID NO:1, the nucleotide sequence of nucleotides 288 to 389 of SEQ ID NO:1, or to the complement of the nucleotide sequence of either nucleotides 66 to 161 of SEQ ID NO:1 or nucleotides 288 to 389 of SEQ ID NO:1.
An isolated polypeptide, comprising an amino acid sequence that shares an identity with the amino acid sequence of SEQ ID NO:2 selected from the group consisting of at least 70% identity, at least 80% identity, at least 90% identity, at least 95% identity, or greater than 95% identity, and wherein any difference between the amino acid sequence of the variant polypeptide and the amino acid sequence of SEQ ID NO:2 is due to one or more conservative amino acid substitutions.
An isolated polypeptide, comprising an amino acid sequence selected from the group consisting of:
- amino acid residues 82 to 108 of SEQ ID NO:2, amino acid residues 28 to 79 of SEQ ID NO:2, amino acid residues 28 to 72 of SEQ ID NO:2, amino acid residues 75 to 78 (amide) of SEQ ID NO:2, and amino acid residues 28 to 79 (amide) of SEQ ID NO:2.
An isolated polypeptide, comprising an amino acid sequence selected from the group consisting of:
- (a) amino acid residues 20 to 105 of SEQ ID NO:5, (b) amino acid residues 18 to 105 of SEQ ID NO:5, (c) amino acid residues 1 to 70 of SEQ ID NO:5, (d) amino acid residues 20 to 70 of SEQ ID NO:5, (e) amino acid residues 18 to 70 of SEQ ID NO:5, (f) amino acid residues 76 to 105 of SEQ ID NO:5, (g) amino acid residues 66 to 105 of SEQ ID NO:5, and (h) amino acid residues 82 to 105 of SEQ ID NO:5.
Dependencies are inferred from the claim text.