Anti-viral conjugate comprising a factor allowing the translocation of a protein across a cell membrane and comprising a single-chain antibody fragment directed against a viral protein
OwnerTimothy John Gilby Brooks, Jacqueline Marie Dugganinventors
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Abstract
A protein conjugate comprising conjugate comprising a first region comprising a factor that permits translocation of a protein across a cell membrane; and a second region comprising a single-chain antibody fragment which has affinity for a viral protein, in particular a viral protein which is necessary for replication of a virus such as a flavivirus.
Claims34
A protein conjugate comprising:
- (i) a first region comprising a factor that permits translocation of a protein across a cell membrane;
- and
- (ii) a second region comprising an single-chain antibody fragment which has affinity for a viral protein.
A protein conjugate according to any one of the preceding claims, wherein the virus is Flavivirus.
A protein conjugate according to any one of the preceding claims wherein the viral protein is a protein necessary for replication of virus.
A protein conjugate according to any one of the preceding claims wherein said viral protein is a non-structural viral protein.
A protein conjugate according to any one of the preceding claims which further comprises a therapeutic agent.
A protein conjugate according to any one of the preceding claims which further comprises an intracellular localisation moiety.
A protein conjugate according to any one of the preceding claims in the form of a fusion protein.
A protein conjugate substantially as hereinbefore described.
Dependencies are inferred from the claim text.