Method of identifying insulin secretion stimulating compounds, and the use of such compounds in treating insulin-secretion related disorders
OwnerShahidul Islaminventor
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Abstract
Calcium Induced Calcium Release (CICR) in β-cells has been found to be a novel target for stimulating insulin secretion in a glucose-dependent manner. The present invention relates to a method of identifying compounds that stimulate insulin secretion in a context-dependent manner based on the finding that compounds stimulating insulin secretion in a glucose-dependent manner are able to elicit periodic amplified Ca2+ release in β-cells. The invention also relates to the use of such compounds, for the manufacture of a medicament for use in the treatment of defective insulin secretion related disorders, especially type 2 diabetes.
Claims20
A method of identifying compounds that stimulate insulin secretion in a context-dependent manner, comprising the steps of:
- A. providing a set of β-cells capable of CICR;
- B. adding a candidate compound to be tested to the cells;
- and
- C. monitoring the cells for periodic amplified Ca2+ release in said cells after addition of the candidate compound of step B.
A method of identifying compounds that stimulate insulin secretion in a context-dependent manner, comprising the steps of:
- A. providing a set of β-cells capable of CICR;
- B. selecting at least one viable/healthy β-cell of said set;
- C. adding a candidate compound to be tested to the cell(s) selected in step B;
- and
- D. monitoring said at least one cell selected in step B for periodic amplified Ca2+ release in said cell after addition of the candidate compound of step C.
Dependencies are inferred from the claim text.