Methods and products useful in the formation and isolation of microparticles
AssigneeSpherics, Inc.
InventorsMichael Bassett, Jules Jacob, David Enscore
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Abstract
A process for preparing nanoparticles, microparticles and nanoencapsulated products using the PIN process is provided. The invention involves using additives to reduce the aggregation or coalescence of the PIN nanoparticles, microparticles, or nanoencapsulated products during their formation and collection and to facilitate the recovery of said nanoparticles, microparticles, or nanoencapsulated products.
Claims89
A method for encapsulating an agent, comprising:
- performing phase inversion nanoencapsulation by combining a polymer and an agent in an effective amount of solvent to form a continuous mixture, and introducing the mixture into an effective amount of a non-solvent containing a dissolved non-solvent soluble polymer to cause the spontaneous formation of a nanoencapsulated product.
The method of claim I wherein the non-solvent soluble polymer is selected from the group consisting of:
- polyvinylpyrrolidone;
- polyethylene glycol;
- starch;
- lecithin;
- modified cellulose;
- and other natural and synthetic water-soluble polymers or glidants.
A method for preparing nanoparticles comprising:
- preparing a solution of non-solvent containing a non-solvent soluble polymer and nanoparticles and removing the non-solvent to produce and collect non-solvent soluble polymer coated nanoparticles.
A suspension of nanoencapsulated product comprising a solution of 0.5% to 10% non-solvent soluble polymer and nanoparticles having an average particle size of less than 10 micrometers.
A composition comprising nanoparticles having an average particle size of less than 10 micrometers and coated with a non-solvent soluble polymer.
A method for encapsulating an agent, comprising:
- performing phase inversion nanoencapsulation by combining a polymer, an aggregation inhibitor and an agent in an effective amount of a solvent to form a continuous mixture, and introducing the continuous mixture into an effective amount of a non-solvent to cause the spontaneous formation of a nanoencapsulated product.
A method for encapsulating an agent, comprising:
- performing phase inversion nanoencapsulation by combining a polymer and an agent in an effective amount of a solvent to form a continuous mixture, and introducing the continuous mixture into an effective amount of a non-solvent to cause the spontaneous formation of a nanoencapsulated product, wherein a water-insoluble aggregation inhibitor is added to the non-solvent.
Dependencies are inferred from the claim text.