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AssigneeJohn-Claude Savoir
InventorsJohn-Claude Savoir, Juan Angeles, Aurelio De Gyves, Abraham Gomez
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The present invention provides storage stable, shaped particles of allotropic organic compounds. The particles of the present invention can be shaped according to the desired application. Preferred shapes of such particles are microspheres, particularly those having diameters of about 1 to about 1,000 microns. The stable shaped particles of the present invention are particularly well-suited to the fabrication of pharmaceutical formulations, particularly where sustained release and uniform bioavailability are desired. The storage stable particles are formed by a solid state crystallization of allotropic organic compounds. The solid state crystallization process of the present invention affords a means for achieving a storage stable crystalline form of said allotropic compound without loss or deterioration of the original particle dimensions.
A method for effecting a solid state crystallization of an allotropic molecular organic compound in a particle of definite size and shape comprising:
A storage stable particle of a definite size and shape and comprising an allotropic organic compound of uniform crystal structure, said organic compound retaining said crystal structure, and said particle retaining said size, and shape on storage in aqueous media for at least about one month.
A method for effecting a solid state crystallization of a mixture containing at least one allotropic molecular organic compound, wherein said mixture has been congealed into a particle of definite size and shape comprising:
Dependencies are inferred from the claim text.