Modified release tamsulosin tablets
OwnerJohannes J. Platteeuw, Frans van Dalen +3inventors
InventorsJohannes J. Platteeuw, Frans van Dalen, Jacobus M. Lemmens, Arturo Siles Ortega, Juan Cucala Escoi
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Abstract
Modified release tablets containing tamsulosin are provided that exhibit reduced or no food effect.
Claims36
A pharmaceutical tablet comprising a tablet matrix having dispersed therein 0.1 to 10 mg of tamsulosin or a pharmaceutically acceptable salt thereof, and optionally having an enteric coating over said matrix, wherein said tablet is a modified release tablet and has a dissolution profile such that in each of the media SIF, FaSSIF, and FeSSIF, said tablet releases not more than 60% of said tamsulosin at 2 hours elapsed time in USP 2 apparatus using 500 ml of said media at 50-100 rpm paddle speed.
A monolithic pharmaceutical tablet, comprising 0.1 to 10 mg of tamsulosin or a pharmaceutically acceptable salt thereof, 10 wt %-90 wt % hydroxypropyl methylcellulose, and a total tablet weight of 10 to 300 mg.
Dependencies are inferred from the claim text.