Eutectic-based self-nanoemulsified drug delivery system
AssigneeJarrow Formulas, Inc.
InventorsMansoor A. Khan, Sami Nazzal
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Abstract
A eutectic-based self-nanoemulsified drug delivery system (SNEDDS) is formulated from polyoxyl 35 castor oil (Cremophor), medium chain mono- and diglycerides (capmul), essential oils, and a pharmacologically effective drug. The preferred pharmacologically effective drug is a poorly water soluble drug, such as ubiquinone (CoQ10). The SNEDDS can be further incorporated into a powder to produce a solid dosage form. The solid dosage form contains the SNEDDS, a copolymer of vinylpyrrolidone and vinyl acetate (Kollidon VA 64), maltodextrin, and microcrystalline cellulose (MCC).
Claims20
A self-nanoemulsified drug delivery system, comprising
- a) 19-26 wt. % of a pharmacologically effective drug;
- b) 23-31 wt. % polyoxyl 35 castor oil;
- c) 23-31 wt. % of a medium chain mono- and diglyderide;
- and
- d) 19-26 wt. % of an essential oil.
Dependencies are inferred from the claim text.