Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
AssigneeThe Regents of the University of California
InventorsDennis A. Carson, Salvatore Albani
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Abstract
Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.
Claims17
A vaccine useful in inducing immune protection against arthritogenic peptides in a host comprising substantially pure dnaJp1 peptide in a pharmaceutically acceptable carrier.
A vaccine useful in inducing immune protection against arthritogenic peptides in a host comprising a recombinant gene expression vector which encodes dnaJp1 peptide.
A method useful in inducing immune protection against arthritogenic peptides in a host comprising administering an immunologically effective amount of dnaJp1 peptide to the host.
A method useful in inducing immune protection against arthritogenic peptides in a host comprising administering a recombinant gene expression vector which encodes dnaJp1 peptide to the host for expression in an immunologically effective amount of dnaJp1 peptide in the host.
A method for determining whether an individual is predisposed to rheumatoid arthritis comprising determining the presence or absence of anti-arthritogenic peptide antibodies in a biological sample obtained from the host by immunoassay of the sample, wherein the presence of such antibodies is indicative of predisposition to rheumatoid arthritis.
A kit for determining whether anti-arthritogenic peptide antibodies are present in a biological sample obtained from an individual comprising labelled anti-dnaJp1 peptide antibodies.
Dependencies are inferred from the claim text.